Osteoarthritis Knee Pain Management

Pain management can often be tricky, as there is considerable overlap of pain mechanisms in the clinical context. Take, for example, the pain of osteoarthritis (OA). Neuropathic origin is generally not considered a feature of OA pain because peripheral nerve injury has not been observed. However, there might be a neuropathic component to OA pain. (1)

In a study of patients with OA of both knees, intra-articular local anesthetic injection in one knee resulted in pain relief in both knees in some patients. This result suggests that, in addition to local mechanisms, there may be central mechanisms to OA pain. (2)  That central sensitization may also play a role in OA pain is suggested by a poor correlation between radiographic evidence of joint damage and severity of pain. (3,4)

Thirty-four percent of patients with chronic knee OA have pain symptoms suggestive of neuropathic pain. (5)  Another study suggests that a subset of patients with OA have neuropathic mechanisms contributing to their OA pain. The diagnosis of neuropathic pain is based on symptoms of spontaneous sensations, such as burning pain, numbness, tingling, itching, sensitivity to heat, cold, touch, and pressure and signs such as hyperalgesia and allodynia. (6)

We have attempted to account for the varying types of pain mechanisms in the development of the Energeze Patch. I recently decided to try the Patch on my osteoarthritis knee pain and found that it provided great relief all day long.  My job requires that I am on my feet walking about in a large clinic and at 60 years of age I have knee pain daily for the last few years.

The Energeze patch provides enough soothing comfort that I no longer need to take over the counter anti-inflammatory pain medications. Similar results have been experienced by countless others in our clinical trials, and we are excited to bring this technology to pain sufferers nationwide!


  1. Im H, Kim J, Li X, et al. 2010. Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum. 62(10):2995-3005.
  2. Creamer P, Hunt M, Dieppe P. 1996. Pain mechanisms in osteoarthritis of the knee: effect of intraarticular anesthetic. J. Rheumatol. 23:1031-1036.
  3. McAlindon TE, Snow S, Cooper C, Dieppe PA. 1992. Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann. Rheum. Dis. 51:844-849.
  4. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. 2008. Cartilage in normal and osteoarthritis conditions. Best Pract. Res. Clin. Rheumatol. 22:351-384.
  5. Hochman JR, French MR, Bermingham SL, Hawker GA. 2010. The nerve of osteoarthritis pain. Arthritis Care Res (Hoboken) 62:1019-1023.
  6. Rasmussen PV, Sindrup SH, Jensen TS, Bach FW. 2004. Symptoms and signs in patients with suspected neuropathic pain. Pain 110:461-469.